Thomas EIWEGGER, MD
Head of the Department Pediatric and Adolescent Medicine, University Hospital St. Poelten, Austria
Chair Division of Pediatrics and Adolescent Medicine, Karl Landsteiner University of Health Sciences Krems, Austria
Associate Professor Dept Pediatrics and Dept Immunology, The University of Toronto
Adjunct Scientist, Translational Medicine Program, Research Institute, SickKids, Toronto
Education:
M.D. Degree: University of Vienna
Postdoctoral Training: Medical University of Vienna and Swiss Institute of Asthma and Allergy Research (SIAF), University of Zurich, Switzerland
Research Interests:
• Immunological mechanisms of Food allergy
• Oral tolerance development and mucosal immunity,
• Immunological mechanisms of oral immunotherapy,
• Diagnostics for allergic diseases,
• Biologics for the treatment of allergic diseases
Biography:
Thomas Eiwegger earned his doctoral degree at the Medical University of Vienna, Austria, where he also completed his paediatric training. He did his post-Doc at the Swiss Institute of Asthma and Allergy in Cezmi Akdis’ group (2008-2010), and after returning to the Medical University of Vienna, he completed his training in Pediatrics, pediatric allergy, and pediatric respiratory medicine. He habilitated in 2012 in Paediatrics. Thereafter, he completed the fast-track tenure at the Medical University of Vienna and worked as principal investigator, group leader, and staff physician at the level of an associate Professor at the Department of Paediatrics and Adolescent Medicine. In the summer of 2015, he moved to the Hospital for Sick Children in Toronto as a clinician-scientist and Co-director of the Food Allergy and Anaphylaxis Program at SickKids.
Since 2021 he has been the head of the Department of Pediatrics at the University Clinics St. Poelten, Associate Professor at the Karl Landsteiner University, Krems and Assoc. Prof, Department of Immunology, University of Toronto, and is an adjunct scientist at the Research Institute at the Hospital for Sick Children in Toronto.
He currently leads research groups in Toronto and Austria that focus on the biomarkers and mechanisms of tolerance development in the context of atopic diseases and novel treatment approaches to food allergy.
Proposed PhD research projects:
Cross-protective effects of peanut and nut oral immunotherapy induced antibody responses
Selected publications:
- Greenhawt M, Sindher SB, Wang J, O'Sullivan M, du Toit G, Kim EH, Albright D, Anvari S, Arends N, Arkwright PD, Bégin P, Blumchen K, Bourrier T, Brown-Whitehorn T, Cassell H, Chan ES, Ciaccio CE, Deschildre A, Divaret-Chauveau A, Dorris SL, Dorsey MJ, Eiwegger T, Erlewyn-Lajeunesse M, Fleischer DM, Ford LS, Garcia-Lloret M, Giovannini-Chami L, Hourihane JO, Jay N, Jones SM, Kerns LA, Kloepfer KM, Leonard S, Lezmi G, Lieberman JA, Lomas J, Makhija M, Parrish C, Peake J, Perrett KP, Petroni D, Pfützner W, Pongracic JA, Quinn P, Robison RG, Sanders G, Schneider L, Sharma HP, Trujillo J, Turner PJ, Tuttle K, Upton JE, Varshney P, Vickery BP, Vogelberg C, Wainstein B, Wood RA, Bee KJ, Campbell DE, Green TD, Rouissi R, Peillon A, Bahnson HT, Bois T, Sampson HA, Burks AW. Phase 3 Trial of Epicutaneous Immunotherapy in Toddlers with Peanut Allergy. N Engl J Med. 2023 May 11;388(19):1755-1766. doi: 10.1056/NEJMoa2212895. (Co-author, Site PI)
- Hung L, Celik A, Yin X, Yu K, Berenjy A, Kothari A, Obernolte H, Upton JEM, Lindholm Bøgh K, Somers GR, Siddiqui I, Grealish M, Quereshy FA, Sewald K, Chiu PPL, Eiwegger T. Precision cut intestinal slices, a novel model of acute food allergic reactions. Allergy. 2022 Nov 14. doi: 10.1111/all.15579. (Project PI)
- Marwaha AK, Laxer R, Liang M, Miuse AM, Eiwegger T & The immune regulation group. A chromosomal duplication encompassing interleukin-33 causes a novel hyper-IgE phenotype characterized by eosinophilic esophagitis and generalized autimmunity. Gastroenterology 2022 DOI 10.1053/j.gastro.2022.04.026 (Project PI)
- Duan L, Celik A, Hoang JA, Schmidthaler K, So D, Yin X, Ditlof CM, Ponce M, Upton JEM, Lee JS, Hung L, Breiteneder H, Palladino C, Atkinson AR, Kim VHD, Berenjy A, Asper M, Hummel D, Wong S, Alexanian-Farr M, Magder A, Chinthrajah SR, Mukai K, Tsai M, Nadeau K, Galli SJ, Ramani AK, Szepfalusi Z, Eiwegger T. Basophil activation test shows high accuracy in the diagnosis of peanut and tree nut allergy: The Markers of Nut Allergy Study. Allergy. 2021 doi: 10.1111/all.14695 (Project PI)
- Bublin M, Kostadinova M, Radauer C, Varga EM, Hafner C, Schmidthaler K, Saidova A, Maleki SJ, Szépfalusi Z, Eiwegger T#, Breiteneder H#. Engineering of structural variants of the major peanut allergens Ara h 2 and Ara h 6 for allergen-specific immunotherapy. JACI 2019 Mar; 143(3): 1226-1229.e10. doi:10.1016/j.jaci.2018.10.039. (#contributed equally corr. Author)
- Ponce M, Schroeder F, BannertC, Schmidthaler K, Hansen CS, Bøgh KL, Soldo R, Tsui SKW, Weinhäusel A, Szépfalusi Z, Eiwegger T. Preventive sublingual immunotherapy with House Dust Mite extract modulates epitope diversity in pre-school children, Allergy. 2018 Nov 5. doi: 10.1111/all.13658 (Project PI)
