Barbara BOHLE, PhD

bohle

Head of the Department of Pathophysiology and Allergy Research, Medical University of Vienna
Head of the Allergy Research group at the Department of Pathophysiology and Allergy Research

Education:
PhD, University Prof. of Cellular Allergology

Research Interests:

• Pathophysiology of IgE-mediated allergy
• Characterization and modification of allergens
• Prevention and therapy of allergic diseases

Biography

Barbara Bohle has studied "Food- and Biotechnology" at the University of Natural Resources and Applied Life Sciences in Vienna after working as a Medical Technical Assistant in the team of Prof. Dietrich Kraft at the Institute of Experimental Pathology, University of Vienna, Austria, for 5 years. In 2000 she received her PhD and in 2002 the Venia docendi in Immunology. Since then she leads the research group “Allergy Research” at the Department of Pathophysiology and Allergy Research at the Medical University of Vienna. In 2010 she was appointed a full professor for Cellular Allergology. Since 2011 she is the Head of the Institute of Pathophysiology and Allergy Research and the Division of Experimental Allergology. From 2007-2015 she led the Christian Doppler Laboratory for Immunomodulation.
The main focus of her scientific work is the elucidation of the immune mechanisms underlying the induction, maintenance and therapy of IgE-mediated allergy. Her scientific work markedly contributed to the understanding of the pathophysiology of pollen-related food allergy and was awarded with prestigious national and international prizes. She is the author of >210 peer-reviewed scientific papers published in highly ranked journals in the field of allergy and immunology. Up to now, 11 PhD theses, 14 diploma/master theses and 14 bachelor theses were completed under her supervision. More information on her current team at https://www.meduniwien.ac.at/hp/ipa/forschung/forschungsgruppen/bohle-barbara-allergy-research/

Proposed PhD research projects:
Prevention of birch pollen and birch-related food allergy

Selected publications:

  1. Demir H, C. Radauer C, Strobl MR, Scheurer S, Kinaciyan T, Bohle B. 2025. Cross-protection of AIT-induced antibodies to related allergens requires a high degree of structural identity. Allergy, doi: 10.1111/all.16323. Online ahead of print
  2. Strobl MR, Demir H, Wozniak-Knopp G, Wangorsch A, Rüker F, Bohle B. 2024. Easy assessment of the avidity of polyclonal allergen-specific serum antibodies. Clin Exp Allergy. 54(4):278-285. doi: 10.1111/cea.14448.
  3. Strobl MR, Demir H, Sánchez Acosta G, Drescher A, Kitzmüller C, Möbs C, Pfützner W, Bohle B. 2023. The role of IgG1 and IgG4 as dominant IgE-blocking antibodies shifts during allergen immunotherapy. J Allergy Clin Immunol. 151(5):1371-1378.e5. doi: 10.1016/j.jaci.2023.01.005.
  4. Strobl MR, Demir H, Stadlmayr G, Stracke F, Hoelzl R, Bohle B, Wozniak-Knopp G. 2023. Affinity matters for IgE-blocking activity of allergen-specific antibodies. Allergy. 78(9):2543-2546. doi: 10.1111/all.15746

Other Publications extlink