Huey-Jy HUANG, PhD
The Center for Molecular Allergology, Karl Landsteiner University of Health Sciences, Krems
Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna
Education:
PhD: PhD-Program Molecular, Cellular and Clinical Allergology, MCCA, Medical University of Vienna, Vienna, Austria
Research Interests:
• Establishment of micro-arrayed allergen chips for investigating allergen sensitization profiles in allergic patients.
• Development of allergen-specific strategies for preventive immunotherapy against allergy
Biography:
Huey-Jy Huang received PhD training in the MCCA program and earned her degree from Medical University of Vienna in 2019. She has been working in the field of house dust mite allergy, focusing on disease mechanisms, serum-based diagnosis, and T-cell epitope-based immunotherapy. More recently, she has focused on the development and application of micro-arrayed allergen chips, which are advanced tools used to investigate IgE sensitizations to a wide array of allergen molecules. These chips generate comprehensive IgE profiles for allergic patients, providing insights into individual sensitization patterns for personalized allergen-based immunotherapy. Additionally, her research focuses on the development of IgE-epitope-based strategies for preventive immunotherapy against allergies in patients with IgE sensitization. Currently, she leads a sub-project within the “Danube Allergy Research Cluster 2.0” and is working on establishing the new lab, “Center for Molecular Allergology (CMA),” at Karl Landsteiner University of Health Sciences in Krems.
Proposed master research projects:
Biochemical and immunological characterization of tree pollen allergens, mold allergens, and cockroach allergens.
Selected publications:
- Huang, HJ., E. Sarzsinszky, S. Vrtala. 2023. House dust mite allergy: The importance of house dust mite allergens for diagnosis and immunotherapy. Mol Immunol. 158:54-67. PMID: 37119758.
- Huang, HJ., Y. Resch-Marat, A. Casset, M. Weghofer, P. Zieglmayer, R. Zieglmayer, P. Lemell, F. Horak, KW. Chen, E. Potapova, PM. Matricardi, G. Pauli, M. Grote, R. Valenta, S. Vrtala. 2022. IgE recognition of the house dust mite allergen Der p 37 is associated with asthma. J Allergy Clin Immunol. 149(3):1031-1043. PMID: 34419535.
- Huang, HJ., R. Campana, O. Akinfenwa, M. Curin, E. Sarzsinszky, A. Karsonova, K. Riabova, A. Karaulov, K. Niespodziana, O. Elisyutina, E. Fedenko, A. Litovkina, E. Smolnikov, M. Khaitov, S. Vrtala, T. Schlederer, R. Valenta R. 2021. Microarray-Based Allergy Diagnosis: Quo Vadis? Front Immunol. 11:594978. PMCID: PMC7928321.
- Huang, HJ., M. Curin, S. Banerjee, KW. Chen, T. Garmatiuk, Y. Resch-Marat, C. Carvalho-Queiroz, K. Blatt, G. Gafvelin, H. Grönlund, P. Valent, R. Campana, M. Focke-Tejkl, R. Valenta, S. Vrtala. 2019. A hypoallergenic peptide mix containing T cell epitopes of the clinically relevant house dust mite allergens. Allergy 74(12):2461-2478. PMID: 31228873; PMCID: PMC7078969.
- Huang, HJ., YL. Lin, CF. Liu, HF. Kao, JY. Wang. 2011. Mite allergen decreases DC-SIGN expression and modulates human dendritic cell differentiation and function in allergic asthma. Mucosal Immunol. 4(5):519-27. PMID: 21471959.
